The decision comes on the heels of Southern Miss' season-opening 32-21 loss to South Alabama on Thursday.
"Coach Hopson came to me after last Thursday’s game to discuss what was on his heart and after much discussion over the weekend, he and I agreed that new leadership for our football program is needed,” Southern Miss athletic director Jeremy McClain said in a school release Monday. “Coach Hopson has been a part of our program for 10 years. I appreciate his commitment to Southern Miss and wish Jay and his family nothing but the best.
Hopson took over as coach of the Golden Eagles in 2016, and had a 28-23 record. Southern Miss reached three bowl games under Hopson, including the Armed Forces Bowl last season. He had a 1-2 bowl record. "After a heartfelt discussion with Jeremy, we have come to a mutual agreement for me to step down as head coach. I am in total agreement with this change in leadership and truly believe it is in the best interest of the players, coaches and this entire program,” Hopson said in a statement. “I cannot thank Bennett and our administration enough for the opportunity that they gave me. I wish Southern Miss nothing but the best and am thankful for all that they have done for me and my family.