Scientists made mice with Y chromosomes female by deleting just 6 tiny molecules

Mammals' chromosomes have a huge influence over whether an individual develops as male or female — but a new study reveals that the pull of these sex chromosomes can be overridden by tiny molecules called microRNAs.

Sex determination in mammals relies on a fine balance between"opposite" sets of genes — one that drives the development of female characteristics, such as ovaries, and another that produces male characteristics, such as testes. Early in an animal's development, the scales tip one way or another, leading to an irreversible cascade of steps that ends in the development of either set of sex organs.

By submitting your information you agree to the Terms & Conditions and Privacy Policy and are aged 16 or over.Long considered "junk DNA," these stretches of genetic material are converted into molecules called non-coding RNA, rather than proteins. The RNA can affect many biological processes. About one-quarter of these molecules are microRNAs, which can attach to numerous genes and regulate their activity levels.

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New UTI vaccine wards off infection for years, early studies suggestSahana Sitaraman is a science writer based in Lausanne, Switzerland, specializing in biology. She particularly enjoys writing about unusual animal behaviours and the neuroscience behind them, mental health and women in STEM. She also dabbles in illustrating cool findings that pique her interest.
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